Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system

Jing Chen; Jessica B. Buchanan; Nathan L. Sparkman; Jonathan P. Godbout; Gregory G. Freund; Rodney W. Johnson

doi:10.1016/j.bbi.2007.08.014

Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system

Jing Chen, Jessica B. Buchanan, Nathan L. Sparkman, Jonathan P. Godbout, Gregory G. Freund, Rodney W. Johnson

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	301-311
Number of pages	11
Journal	Brain, Behavior, and Immunity
Volume	22
Issue number	3
DOIs	https://doi.org/10.1016/j.bbi.2007.08.014
State	Published - Mar 2008
Externally published	Yes

ASJC Scopus Subject Areas

Immunology
Endocrine and Autonomic Systems
Behavioral Neuroscience

Keywords

Aging
Hippocampus
Interleukin-1
Laser capture microdissection
Lipopolysaccharide
Working memory

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10.1016/j.bbi.2007.08.014

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@article{d848e269f8bd4ed1bd7e4c52125ed8cf,

title = "Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system",

keywords = "Aging, Hippocampus, Interleukin-1, Laser capture microdissection, Lipopolysaccharide, Working memory",

author = "Jing Chen and Buchanan, {Jessica B.} and Sparkman, {Nathan L.} and Godbout, {Jonathan P.} and Freund, {Gregory G.} and Johnson, {Rodney W.}",

note = "Funding Information: We thank Dr. James Zachary for assisting with LCM and Dr. Masaaki Nakai (University of Illinois) for helping with IHC staining. Dr. Colm Cunningham at University of Southampton (U.K.) also provided helpful advice on IHC staining. This research was supported by NIH grants AG16710 (R.W.J.), AG023580 (R.W.J.), MH069148 (R.W.J.) and DK64862 (G.G.F.). J.B.B. and J.P.G. were supported by a Ruth L. Kirchstein NRSA Postdoctoral Fellowship.",

year = "2008",

month = mar,

doi = "10.1016/j.bbi.2007.08.014",

language = "English",

volume = "22",

pages = "301--311",

number = "3",

}

TY - JOUR

T1 - Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system

AU - Chen, Jing

AU - Buchanan, Jessica B.

AU - Sparkman, Nathan L.

AU - Godbout, Jonathan P.

AU - Freund, Gregory G.

AU - Johnson, Rodney W.

N1 - Funding Information: We thank Dr. James Zachary for assisting with LCM and Dr. Masaaki Nakai (University of Illinois) for helping with IHC staining. Dr. Colm Cunningham at University of Southampton (U.K.) also provided helpful advice on IHC staining. This research was supported by NIH grants AG16710 (R.W.J.), AG023580 (R.W.J.), MH069148 (R.W.J.) and DK64862 (G.G.F.). J.B.B. and J.P.G. were supported by a Ruth L. Kirchstein NRSA Postdoctoral Fellowship.

PY - 2008/3

Y1 - 2008/3

KW - Aging

KW - Hippocampus

KW - Interleukin-1

KW - Laser capture microdissection

KW - Lipopolysaccharide

KW - Working memory

UR - http://www.scopus.com/inward/record.url?scp=38649119160&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38649119160&partnerID=8YFLogxK

U2 - 10.1016/j.bbi.2007.08.014

DO - 10.1016/j.bbi.2007.08.014

M3 - Article

C2 - 17951027

AN - SCOPUS:38649119160

SN - 0889-1591

VL - 22

SP - 301

EP - 311

JO - Brain, Behavior, and Immunity

JF - Brain, Behavior, and Immunity

IS - 3

ER -

Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system

ASJC Scopus Subject Areas

Keywords

Access to Document

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