Palladium and Iron Cocatalyzed Aerobic Alkene Aminoboration

Brittany L. Gay; Ya Nong Wang; Shreeja Bhatt; Anika Tarasewicz; Daniel J. Cooke; E. Grace Milem; Bufan Zhang; J. Brannon Gary; Michael L. Neidig; Kami L. Hull

doi:10.1021/jacs.3c05790

Palladium and Iron Cocatalyzed Aerobic Alkene Aminoboration

Brittany L. Gay, Ya Nong Wang, Shreeja Bhatt, Anika Tarasewicz, Daniel J. Cooke, E. Grace Milem, Bufan Zhang, J. Brannon Gary, Michael L. Neidig, Kami L. Hull

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Aminoboration of simple alkenes with nitrogen nucleophiles is a challenge in synthetic chemistry. Although palladium can catalyze this transformation, it faces stability issues. A new method using a combination of palladium and iron as cocatalysts has been developed to address this. The iron cocatalyst plays a key role in achieving the desired reaction and in regenerating the palladium catalyst. This method has been successfully demonstrated on various alkenes and nitrogen nucleophiles.

Original language	English
Pages (from-to)	18939-18947
Number of pages	9
Journal	Journal of the American Chemical Society
Volume	145
Issue number	34
DOIs	https://doi.org/10.1021/jacs.3c05790
State	Published - Aug 30 2023

ASJC Scopus Subject Areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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title = "Palladium and Iron Cocatalyzed Aerobic Alkene Aminoboration",

abstract = "Aminoboration of simple alkenes with nitrogen nucleophiles is a challenge in synthetic chemistry. Although palladium can catalyze this transformation, it faces stability issues. A new method using a combination of palladium and iron as cocatalysts has been developed to address this. The iron cocatalyst plays a key role in achieving the desired reaction and in regenerating the palladium catalyst. This method has been successfully demonstrated on various alkenes and nitrogen nucleophiles.",

author = "Gay, {Brittany L.} and Wang, {Ya Nong} and Shreeja Bhatt and Anika Tarasewicz and Cooke, {Daniel J.} and Milem, {E. Grace} and Bufan Zhang and Gary, {J. Brannon} and Neidig, {Michael L.} and Hull, {Kami L.}",

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T1 - Palladium and Iron Cocatalyzed Aerobic Alkene Aminoboration

AU - Gay, Brittany L.

AU - Wang, Ya Nong

AU - Bhatt, Shreeja

AU - Tarasewicz, Anika

AU - Cooke, Daniel J.

AU - Milem, E. Grace

AU - Zhang, Bufan

AU - Gary, J. Brannon

AU - Neidig, Michael L.

AU - Hull, Kami L.

PY - 2023/8/30

Y1 - 2023/8/30

N2 - Aminoboration of simple alkenes with nitrogen nucleophiles is a challenge in synthetic chemistry. Although palladium can catalyze this transformation, it faces stability issues. A new method using a combination of palladium and iron as cocatalysts has been developed to address this. The iron cocatalyst plays a key role in achieving the desired reaction and in regenerating the palladium catalyst. This method has been successfully demonstrated on various alkenes and nitrogen nucleophiles.

AB - Aminoboration of simple alkenes with nitrogen nucleophiles is a challenge in synthetic chemistry. Although palladium can catalyze this transformation, it faces stability issues. A new method using a combination of palladium and iron as cocatalysts has been developed to address this. The iron cocatalyst plays a key role in achieving the desired reaction and in regenerating the palladium catalyst. This method has been successfully demonstrated on various alkenes and nitrogen nucleophiles.

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SP - 18939

EP - 18947

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 34

ER -

Palladium and Iron Cocatalyzed Aerobic Alkene Aminoboration

Abstract

ASJC Scopus Subject Areas

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