Palladium and Iron Cocatalyzed Aerobic Alkene Aminoboration

Brittany L. Gay; Ya Nong Wang; Shreeja Bhatt; Anika Tarasewicz; Daniel J. Cooke; E. Grace Milem; Bufan Zhang; J. Brannon Gary; Michael L. Neidig; Kami L. Hull

doi:10.1021/jacs.3c05790

Palladium and Iron Cocatalyzed Aerobic Alkene Aminoboration

Brittany L. Gay, Ya Nong Wang, Shreeja Bhatt, Anika Tarasewicz, Daniel J. Cooke, E. Grace Milem, Bufan Zhang, J. Brannon Gary, Michael L. Neidig, Kami L. Hull

Chemistry and Biochemistry

Producción científica: Article › revisión exhaustiva

Resumen

Aminoboration of simple alkenes with nitrogen nucleophiles is a challenge in synthetic chemistry. Although palladium can catalyze this transformation, it faces stability issues. A new method using a combination of palladium and iron as cocatalysts has been developed to address this. The iron cocatalyst plays a key role in achieving the desired reaction and in regenerating the palladium catalyst. This method has been successfully demonstrated on various alkenes and nitrogen nucleophiles.

Idioma original	English
Páginas (desde-hasta)	18939-18947
Número de páginas	9
Publicación	Journal of the American Chemical Society
Volumen	145
N.º	34
DOI	https://doi.org/10.1021/jacs.3c05790
Estado	Published - ago 30 2023

ASJC Scopus Subject Areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

Acceder al documento

10.1021/jacs.3c05790

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AU - Gay, Brittany L.

AU - Wang, Ya Nong

AU - Bhatt, Shreeja

AU - Tarasewicz, Anika

AU - Cooke, Daniel J.

AU - Milem, E. Grace

AU - Zhang, Bufan

AU - Gary, J. Brannon

AU - Neidig, Michael L.

AU - Hull, Kami L.

PY - 2023/8/30

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AB - Aminoboration of simple alkenes with nitrogen nucleophiles is a challenge in synthetic chemistry. Although palladium can catalyze this transformation, it faces stability issues. A new method using a combination of palladium and iron as cocatalysts has been developed to address this. The iron cocatalyst plays a key role in achieving the desired reaction and in regenerating the palladium catalyst. This method has been successfully demonstrated on various alkenes and nitrogen nucleophiles.

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